When a professor develops a vaccine that eliminates human allergies to dogs, he unwittingly upsets the fragile balance of power between cats and dogs and touches off an epic battle for pet supremacy. The fur flies as the feline faction, led by Mr. Tinkles, squares off against wide-eyed puppy Lou and his canine cohorts.
Jeff Goldblum
Elizabeth Perkins
Alexander Pollock
Miriam Margolyes
Tobey Maguire
Alec Baldwin
Sean Hayes
Susan Sarandon
Joe Pantoliano
Michael Clarke Duncan
Jon Lovitz
Charlton Heston
Glenn Ficarra
Billy West
John Michael Higgins
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